Research Progress of Tirofiban Combined with Mechanical Thrombectomy in the Treatment of Acute Ischemic Stroke
In acute ischemic stroke patients with large vessel occlusion,mechanical thrombectomy can improve the hemodynamic status and clinical symptoms within the effective time,but mechanical thrombectomy is often associated with vascular re-occlusion,which affects the prognosis of patients.Platelet glycoprotein Ⅱb/Ⅲa(GPⅡb/Ⅲa)receptor antagonists prevent vascular re-occlusion by inhibiting the last common pathway of platelet aggregation.At present,the effects of GPⅡb/Ⅲa receptor antagonists on the clinical outcome during the perioperative period of mechanical thrombectomy in ischemic stroke remain controversial.This paper reviewd the efficacy and safety of tirofiban,a GPⅡb/Ⅲa receptor antagonist,in the treatment of vascular re-occlusion after mechanical thrombectomy in acute ischemic stroke.It was found that tirofiban combined with mechanical thrombectomy was safe for the treatment of acute ischemic stroke,but its therapeutic effectiveness still needs to be confirmed by standardized clinical research evidence.
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