Challenges in Basic and Clinical Research of Moyamoya Disease
Moyamoya disease is a chronic progressive cerebrovascular disease of unknown etiology,which is most prevalent in children and young adults in East Asia.Over the past two decades,there have been rapid advancements in basic and clinical research on Moyamoya disease,leading to groundbreaking developments,particularly in susceptible gene studies.However,while progress has been made,there are still many problems and challenges.Is genetic testing necessary?What are the differences between Moyamoya disease in children and adults?Are asymptomatic patients truly asymptomatic?Can Moyamoya disease be clearly distinguished from Moyamoya syndrome?Can patients with hemorrhagic Moyamoya disease benefit from surgery?A series of questions continue to perplex clinicians in the field.In the future,researchers need to conduct high-quality basic and clinical research to dispel the"fog"surrounding the diagnosis and treatment of Moyamoya disease.