Comparative Study on the Safety and Prognosis of Drug-Coated Balloon Angioplasty and Conventional Balloon Angioplasty in the Treatment of Symptomatic Intracranial Atherosclerotic Stenosis
Objective To compare the safety and prognosis of drug-coated balloon(DCB)angioplasty and conventional balloon angioplasty in treating symptomatic intracranial atherosclerotic stenosis.Methods The patients with symptomatic severe intracranial atherosclerotic stenosis who were treated at The Affiliated Hospital of Qingdao University from March 2020 to April 2022 were retrospectively analyzed.Patients were divided into the DCB group and the conventional balloon group according to the treatment method.The general clinical data,efficacy,and safety endpoints,including perioperative complications,clinical outcomes,and imaging results during follow-up,were compared between the two groups.Results A total of 49 patients were included in the study,including 30 in the DCB group and 19 in the conventional balloon group.There were no significant differences in baseline data and perioperative complications,as well as stroke recurrence rate,restenosis rate and mortality within 6 months after surgery between the two groups(P＞0.05).The DCB group exhibited a lower degree of restenosis at 14.50％(9.55％-23.42％),as compared to 30.00％(15.42％-37.61％)in the conventional balloon group,with a statistically significant difference(P=0.027).Conclusions In comparison to conventional balloon treatment,DCB treatment is considered safe for symptomatic severe intracranial atherosclerotic stenosis and can effectively reduce the progress of target vessel restenosis.
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