Research Progress of Exosomes in Alleviating Secondary Injury of Hemorrhagic Cerebrovascular Disease
At present,there are many surgical interventions in the clinical practice for hemorrhagic cerebrovascular diseases,but patients still have different degrees of neurological damage after treatment.Therefore,it is very important to find a way to reduce the secondary injury of patients effectively.With the development of regenerative medicine,the introduction of the concept of exosomes provided new ideas and directions for the diagnosis and treatment of hemorrhagic cerebrovascular diseases.As a kind of extracellular vesicle,exosomes can carry intracellular substances and play a role in information transmission among cells.More importantly,exosomes can freely cross the blood-brain barrier,thus playing a regulatory role in nervous system-related diseases.Therefore,this paper mainly reviewed four pathophysiological mechanisms of exosomes in alleviating secondary injury of hemorrhagic cerebrovascular diseases,including inhibiting inflammatory reaction,reducing programmed cell death,protecting the blood-brain barrier,and alleviating oxidative stress damage,and summarized their application prospects in clinical diagnosis and treatment.
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