Sneddon syndrome is a rare neurocutaneous syndrome that mainly involves the small and medium arteries.It is clinically characterized by widespread livedo reticularis with recurrent ischemic strokes.This case described a young woman who has suffered multiple minor strokes over the past decade,accompanied by spinal subarachnoid hemorrhage and multiple intracranial aneurysms.Genetic testing revealed a heterozygous mutation in the adenosine deaminase 2(ADA2)(c.1240G＞A).The patient had been treated with clopidogrel for antiplatelet aggregation but later discontinued the therapy.For young patients with a history of recurrent strokes,physicians should closely observe and inquire about the skin lesions in detail and recommend cerebral angiography and genetic testing to more comprehensively assess and manage such cases.
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