Serological analysis of severe acute respiratory syndrome coronavirus 2-specific immunoglobulin G antibodies level in Henan Province
Objective To analyze the specific immunoglobulin G(IgG)antibodies level in the population after the coronavirus disease 2019(COVID-19)pandemic in Henan Province.Methods A total of 5 178 peripheral venous blood samples were collected from 10 districts(counties)in Henan Province according to the national seroepidemiological survey program for COVID-19,and the method of cluster random sampling was adopted from March 6 to 15,2023.Descriptive analysis was used for the basic data,history of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccination,SARS-CoV-2 infection of the respondents.The specific IgG antibody of SARS-CoV-2 was detected using chemiluminescence method.Statistical analysis was performed by using rank sum test,Kruskal Wallis test,and Dunn's test.Results The overall positive rate of SARS-CoV-2-specific IgG antibody was 83.35％(4 316/5 178).There were statistically significant differences in the specific IgG antibodies against SARS-CoV-2 produced by people of different sexes,different ages,infected or not,vaccinated or not,and vaccinated with different doses of SARS-CoV-2 vaccine(Z=3.60,H=195.32,Z=6.10,18.08,H=382.70,respectively,all P＜0.001).The specific IgG antibodies produced by unvaccinated+uninfected group,unvaccinated+infected group,vaccinated+uninfected group,and vaccinated+infected group were 3.54(0.98,11.00),60.65(2.33,84.80),133.00(59.80,173.00),and 142.00(98.30,176.00),respectively.And the difference was statistically significant(H=354.62,P＜0.001).The specific IgG antibodies of uninfected people increased with the increase of inoculum times(H=287.00 and 98.48,both P＜0.001).The specific IgG antibodies of people who were not infected with SARS-CoV-2 in the groups of whose interval from the last inoculation of SARS-CoV-2 vaccine to blood collection was less than three months,three to six months and more than six months were 171.86(156.04,196.57),71.71(17.08,110.38)and 132.14(57.59,172.25),respectively,and the difference was statistically significant(H=19.93,P＜0.001).Among them,the absolute difference between the less than three months group and the three to six months group was statistically significant(Z=3.67,P＜0.001),and the absolute difference between the less than three months group and the more than six months group was statistically significant(Z=3.47,P＜0.001).The specific IgG antibodies level in the less than three months group was the highest.Conclusions There is a certain correlation between the number of SARS-CoV-2 vaccine doses and the specific IgG antibodies level in uninfected people.The specific IgG antibodies could maintain a high level for three months after immunization.
Severe acute respiratory syndrome coronavirus 2IgG antibodiesCross section survey
NETL
NSTL
万方数据
