Objective To investigate the clinical efficacy of the bone-forming channel technique com-bined with double plates in the treatment of postoperative aseptic nonunion of the humeral shaft.Methods A retrospective study was conducted to analyze the data of 39 patients with postoperative aseptic nonunion of the humeral shaft who had been treated by bone-forming channel technique combined with double plates from March 2018 to December 2022.There were 20 males and 19 females,with an age of(46.5±1.6)years.The bone nonunion was atrophic in 18 cases and hypertrophic in 21 cases.The operation time,intraoperative bleed-ing,fracture healing time and complications were recorded.The shoulder and elbow functions were evaluated before operation and at the final follow-up using the Disabilities of the Arm,Shoulder and Hand(DASH)score,Neer's shoulder function score,and Mayo's elbow performance score(MEPS).Results All the 39 pa-tients were followed up for an average duration of(13.8±3.5)months.The operation time was(84.3±7.3)minutes,the intraoperative bleeding(127.5±4.5)mL,the fracture healing time(24.4±1.3)weeks,and the fracture healing rate 100%(39/39).None of the patients had such postoperative complications as infec-tion,neurovascular injury,or re-rupture of internal fixation.At the final follow-up,the patients'DASH score[(7.4±1.2)points],Neer's shoulder function score[(93.4±5.2)points],and MEPS[(94.6±3.3)points]were significantly improved compared respectively with the preoperative values[(26.6±8.4)points,(74.3±6.5)points,and(73.8±5.3)points](P<0.05).At the final follow-up,the patients'forward flexion and upward mobility was 168.5°±3.4°,abduction and upward mobility was 167.5°±5.2°,and hori-zontal forward flexion was 129.5°±11.8°.Conclusion In the treatment of postoperative aseptic nonunion of the humeral shaft,since the bone-forming channel technique combined with double plates can achieve satisfactory clinical outcomes,it is worthy of clinical application.