摘要
目的 分析原发性膝关节骨关节炎(KOA)严重程度的危险因素.方法 回顾性分析2015年1月至2022年12月唐山市第二医院治疗的4 057例原发性KOA患者资料.将患者根据Kell-gren-Lawrence 分级分为轻型(Kellgren-Lawrence 分级 Ⅱ级)组、中型(Kellgren-Lawrence 分级 Ⅲ 级)组及重型(Kellgren-Lawrence分级Ⅳ级)组.纳入3组患者的基础资料和入院3 d以内的实验室指标进行单因素分析,通过logistic回归分析筛选出原发性KOA的危险因素.结果 单因素分析结果显示,年龄、原发性高血压、冠状动脉粥样硬化性心脏病、糖尿病、吸烟、血型、红细胞沉降率(ESR)、补体C3、IgM、类风湿因子(RF)、总蛋白、C-反应蛋白(CRP)3组间比较差异均有统计学意义(P＜0.05).logistic回归分析结果表明,年龄以40～49岁为参照,50～59岁、60～69岁、≥ 70岁年龄组与原发性KOA严重程度存在正向关联(OR=1.866,95％CI:1.379～2.527;OR=4.259,95％CI:3.168～5.726;OR=7.486,95％CI:5.403～10.360);原发性高血压、AB血型、IgM水平异常及ESR、RF、CRP水平的升高与原发性 KOA 严重程度均存在正向关联(OR=1.550,95％Cl:1.366～1.756;OR=1.265,95％Cl:1.103～1.451;OR=1.385,95％CI:1.217～1.579;OR=1.385,95％CI:1.217～1.579;OR=1.252,95％CI:1.026～1.528;OR=1.276,95％CI:1.013～1.608).结论 年龄增长、患原发性高血压、AB血型、IgM水平异常、ESR水平升高、RF水平升高、CRP水平升高均为原发性KOA严重程度的危险因素.
Abstract
Objective To analyze the risk factors for the severity of primary knee osteoarthritis(KOA).Methods A retrospective study was conducted to analyze the 4,057 patients with primary KOA who had been treated at The Second Hospital of Tangshan from January 2015 to December 2022.The patients were divided into 3 groups based on their Kellgren Lawrence classification:a mild group(Kellgren Lawrence grade Ⅱ),a moderate group(Kellgren Lawrence grade Ⅲ),and a severe group(Kellgren Lawrence grade Ⅳ).Univariate analysis was conducted of the basic data and laboratory indicators within 3 days after admission of the 3 groups of patients.Multivariate logistic regression analysis was conducted to identify the risk factors for pri-mary KOA.Results The univariate analysis showed that there were significant differences among the 3 groups in age,primary hypertension,coronary atherosclerotic heart disease,diabetes,smoking,blood type,erythrocyte sedimentation rate(ESR),complement C3,IgM,rheumatoid factor(RF),total protein,and C-reactive protein(CRP)(P＜0.05).The multivariate logistic regression analysis showed that there was a positive correlation between the severity of primary KOA and the age groups of 50 to 59 years old,60 to 69 years old,and ≥ 70 years old,with a reference age of 40 to 49 years old(OR=1.866,95％CI:1.379 to 2.527;OR=4.259,95％CI:3.168 to 5.726;OR=7.486,95％CI:5.403 to 10.360)and that there was a positive correlation between primary hypertension,AB blood type,abnormal IgM levels,and el-evated levels of ESR,RF,and CRP with the severity of primary KOA(OR=1.550,95％CI:1.366 to 1.756;OR=1.265,95％CI:1.103 to 1.451;OR=1.385,95％CI:1.217 to 1.579;OR=1.385,95％CI:1.217 to 1.579;OR=1.252,95％CI:1.026 to 1.528;OR=1.276,95％CI:1.013 to 1.608)Conclusions Aging,primary hypertension,AB blood type,abnormal IgM levels,elevated ESR levels,elevated RF levels,and elevated CRP levels are all risk factors for the severity of primary KOA.
维普
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