Objective To summarize the clinical characteristics and factors that may affect the flare of patients with systemic lupus erythematosus(SLE).Methods A total of 300 patients with SLE who were treated with standard treatment in the outpatient clinic of the department of rheumatology and immunology of the Second Affiliated Hospital of Air Force Military Medical University of PLA,were enrolled,and the patients were divided into 24 patients in the complete response group,40 cases in the no response group,192 cases in the treatment response group,and 44 cases in the low disease activity group according to the response to treatment.The differences in clinical characteristics and survival rates between the groups were compared and analyzed.Comparisons of count data were made using analysis of variance(ANOVA),comparisons of measurement data were made using the chi-square test or the Fisher's ecact test,and survival rates were expressed as Kaplan-Meier curves.Cox regression analysis was adapted to explore risk factors for flare in these patients.Results A total of 300 patients were followed.With a median follow-up time of 18(1,36)months,a total of 42 patients experienced flare.The clinical characteristics of the four groups were compared,and there were significant differences in age(F=4.39,P=0.005),the presence of lupus nephritis(x2=12.66,P=0.005),hemoglobin level(F=2.73,P=0.044),NLR level(F=3.88,P=0.010),cystatin C level(F=3.11,P=0.027),anti-RNP antibody(x2=12.04,P=0.007),anti-Sm antibody(x2=8.33,P=0.040),anti-SSB antibody(P=0.014),anti-nucleosome antibody(P=0.014),and anti-ribosomal P protein antibody(x2=11.83,P=0.008).There was no significant difference in survival between the four groups.Cox analysis showed that the combination of other autoimmune diseases[HR(95％CI)=3.23(1.58,6.57),P=0.001],anti-Sm antibody[HR(95％CI)=2.15(1.04,4.43),P=0.038],and anti-RNP antibody[HR(95％CI)=2.54(1.13,5.68),P=0.023]were risk factors for flare in patients with SLE who could reach the treatment target.Conclusion Patients with SLE with different treatment responses have different clinical features,and all treatment can significantly improve the recurrence rate no matter what level of response to treatment.Patients concurrent with other autoimmune diseases,positive anti-Sm antibodies,and positive anti-RNP antibodies are at highrisk of flare.
Lupus erythematosus,systemicFlareTreat to targetSurvival analysisClinical char-acteristicCox regression analysis
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