Objective To study the clinical and immunological features of two case of rare antisynthetase syndrome(ASS),so as to improve the level of diagnosis and treatment.Methods Two cases with rare antisynthetase syndrome admitted to the First Affiliated Hospital of Zhengzhou University from July 2020 to August 2022 were collected.Results The two rare ASS were anti-Zo antibody and anti-Ha antibody positive patients,both of which had interstitial lung disease(ILD)as the main clinical manifestation and positive anti-Ro52 antibody.Two rare antisynthetase autoantibodies manifested cytoplasmic ANA indirect immunofluorescence(IIF)staining pattern,but it is different from the cytoplasmic dense speckled pattern of several common ASS antibodies.After treatment with glucocorticoids and immunosuppressants,case 1 died of respiratory failure due to a long course of disease and late diagnosis,the lung lesions of case 2 improved significantly.Conclusion When encountering the cytoplasmic ANA fluorescent pattern in ILD patients,especially with anti-Ro52 antibody,it is necessary to screen more myositis specific antibodies to rule out the possibility of rare ASS.
Antisynthetase syndromeAnti-aminoacyl tRNA synthetase antibodyAnti Zo antibodyAnti Ha antibodyLung disease,interstitial
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