The clinical significance of the immunogolobulin-like transcript 2 expression in natural killer T cells from patients with systemic lupus erythematosus
Objective To investigate the clinical significance of the immunoglobulin-like transcript2(ILT2)expression in natural killer T cells from patients with systemic lupus erythematosus(SLE).Methods Fifty patients with SLE from January 2022 to July 2022 in Shengli Clinical Medical College of Fujian Medical University and 24 healthy controls were enrolled.The expression of NK cells,NKT cells,ILT2+NK cells,and ILT2+NKT cells were detected by flow cytometry.The changes of ILT2+NKT cells were observed in 6 patients with infection after treatment.Data were analyzed by t test and Pearson correlation analysis.Results The expression of NKT cells in the peripheral blood of patients was lower than that in the controls[(1.5±1.7)％vs.(2.5±1.2)％,t=2.54,P=0.013].The level of ILT2+NKT cells was obviously higher[(70±17)％vs.(54±20)％,t=3.43,P=0.001].The level of ILT2+NKT cells were positively correlated with SLEDAI(r=0.28,P=0.046),serum creatinine(r=0.30,P=0.031),and negatively correlated with complement C3(r=-0.32,P=0.022).ILT2+NKT cells significantly increased in SLE patients with infection[(79.2±12.4)％vs.(65.1±1.0)％,t=2.84,P=0.007],and decreased after anti-infection treatment[(85±7)％vs.(69±6)％,t=3.45,P=0.001].Conclusion The expression of peripheral ILT2+NKT cells in SLE patients is higher than that in healthy controls,and is related to disease activity indicators.The expression of ILT2+NKT cells in SLE patients infection is increased significantly,and decreased after anti-infection treatment.It is suggested that the overexpression of ILT2 in NKT cells may participate in the occurrence and development of SLE diseases,and may be related to the occurrence of infection.
Lupus erythematosus,systemicNatural killer T cellsImmunogolobulin-like transcript2
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