Objective Retrospective analyzed the characteristics of 202 patients with interstitial lung disease(ILD)in systemic sclerosis(SSc),studied the relationship between their characteristics in different types of SSc-ILD and vascular disease and antibody,in order to increase the understanding of SSc-ILD.Methods A total of 249 inpatients with SSc in our hospital from May 2021 to September 2022 were invloved.By comparing SSC-ILD with SSc-non-ILD groups and different types in SSc-ILD groups,to analyze the relationship between their characteristics of SSc-ILD and vascular disease and auto-antibody.According to the data type,the paired sample t test,Wilcoxon signed rank sum test,ANOVA analysis of variance or Chi-square test were used for statistical analysis.The statistical analysis software to analyze the relationship between their characteristics of SSc-ILD and vascular disease and auto-antibody.According to the data type,the paired sample t test,Wilcoxon signed rank sum test,or Chi-square test were used for statistical analysis.Results In this study,among 202 patients with SSC-ILD,183 were female(90.6％),and among 47 patients with SSc-non-ILD,36 were female(76.6％).The incidence of ILD in female SSc patients was significantly higher than that in male patients(x2=7.05,P=0.008).The chest high-resolution CT(HRCT)showed that ground glass was the most common presentation(90.1％).The incidence of interlobular septum thickening and reticular shadow were more than 70.0％.The incidence of interlobular thickening and bronchial distraction was higher than 50.0％.The pulmonary fibrosis score[23.77(10.69,36.54)]in the usual interstitial pneumonia(UIP)group was higher than that in the nonspecific interstitial pneumonia(NSIP)group[12.63(3.44,17.89)](Z=5.19,P＜0.001).The pulmonary fibrosis score[18.55(6.52,26.06)]in the nonspecific interstitial pneumonia(the fibrotic type)(f-NSIP)group was higher than that in the nonspecific interstitial pneumonia(cellular type)(c-NSIP)group[5.27(1.15,7.55),Z=7.59,P＜0.001].The score of pulmonary fibrosis was positively correlated with the age of onset of SSc(r=0.02,P=0.021).The incidence of telangiectasia(37.5％vs.19.9％,x2=2.60,P=0.009),skin ulcer(48.2％vs.31.5％,x2=2.21,P=0.027)and phalangeal resorption(51.8％vs.28.1％,x2=3.17,P=0.002)in UIP patients was higher than that of NSIP.The incidence of telangiectasia(27.2％vs.10.8％,x2=2.26,P=0.024)and phalangeal resorptive(35.8％vs.18.5％,x2=2.32,P=0.021)in the f-NSIP group was higher than that in the c-NSIP group.The positive rate of anti-SCL-70 antibody in SSC-ILD patients(76.2％vs.23.4％)was significantly higher than that in SSc non-ILD patients(x2=47.61,P＜0.001).The positive rate of anti-centromere antibody in SSc non-ILD group(31.9％vs.11.4％)was significantly higher than that in SSC-ILD group(x2=12.42,P=0.001).There was a significant difference in the positive rate of anti-SSB antibody in SSc-ILD group(9.9％vs.0,P=0.025).Conclusion Positive anti-SCL-70 antibody is directly related to the occurrence of SSC-ILD,and positive anti-SSB antibody may be a risk factor for ILD in patients with SSc.
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