Objective To evaluate the clinical value of CD4+T lymphocyte subsets such as helper Th2 in patients with recurrent uveitis(BU)in Behçet's disease(BD).Methods The clinical data of 153 hospitalized patients diagnosed with Behçet's disease from January 1,2020 to June 30,2023 in the Second Hospital of Shanxi Medical University were retrospectively analyzed.The subsets of CD4+T lymphocytes were measured,including helper T cells(Th cells)such as Th1,Th2,Th17 and regulatory T cells(Treg cells),biochemical lipid indexes(TC,TG,etc.),the frequency of oral ulcers in the past 1 year,the frequency of genital ulcers in the past 1 year,and drug use before admission;According to whether there was ocular involvement and uveitis,153 cases of BD were divided into Behçet non-uveitis group(non-BU group)and Behçet uveitis group(BU group).The above indexes and independent correlation factors of recurrent BU were compared between BU group and non-BU group;The above indexes and independent correlation factors of recurrent BU were compared between BU group and non-BU group.The levels of cytokines and ICBD total score,the correlation between ICBD total score and various cytokines,and the diagnostic performance of Th2 cells were compared between BU group and non-BU group.The statistical methods were Mann-Whitney U test,independent sample t test,Chi-square test,multiple logistic regression analysis,Pearson correlation analysis and receiver operating characteristic curve(ROC)analysis.Results ①The levels of Th1,Th2.Th17 cells,TC and TG in BU group were higher than those in non-BU group[133.87(93.38,229.87)/μl vs.102.51(64.25,149.23)/μl]and[9.43(5.84,14.13)/μl vs.6.78(4.23,9.44)/μl],[15.53(9.36,25.27)/μl vs.9.83(5.46,14.76)/μl],[4.21(3.89,4.90)mmol/L vs.3.89(3.37,4.34)mmol/L)],[1.43(1.00,2.21)mmol/L vs.0.96(0.69,1.38)mmol/L],The differences were statistically significant(Z=-3.24,Z=-3.05,Z=-3.94,Z=-2.25,Z=-3.47;all P＜0.05);There was no statistical significance in Chi-square test between the two groups(x2=5.69,P＞0.05).②The levels of IL-2,IL-10 and total ICBD score in BU group were higher than those in non-BU group,with statistical significance(Z=-2.12,Z=-2.29,t=-6.48;all P＜0.05).③ The results of multiple logistic regression analysis showed that Th2 was an independent correlation factor for BU[OR value(95％CI)was 1.143(1.007,1.298),P=0.039].The total score of BU patients was correlated with Th2 and Th17 cells.ROC analysis showed that the sensitivity of Th2 in diagnosing BU was 68.8％,the specificity was 49.5％and the area under the curve(95％CI)was 0.697(0.585,0.809)(P=0.001).Conclusion CD4+T lymphocyte subsets such as the absolute number of Th2 cells are related to BU,which is an important indicator to observe the severity of disease progression in BU patients,and has certain clinical value in evaluating the recurrence of BU in BD patients.
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