Objective To investigate the clinical characteristics of multiple sclerosis(MS)patients with positive anti-SSA antibody.Methods The data of patients with positive anti-SSA antibody hospitalized in Beijing Tiantan Hospital between December 2011 and May 2020 were retrieved.Patients who fulfilled the diagnosis of MS were enrolled.MS patients with negative anti-SSA antibody hospitalized in the same period were matched based on gender and age in a ratio of 1∶2.The clinical characteristics of MS patients with positive anti-SSA antibody and those with negative anti-SSA antibody were compared.We used SPSS 24.0 statistical software to perform data analysis.The Shapiro-Wilk test was used to determine whether continuous variables conform to a normal distribution.The group differences of non-normal distribution of measurement data were analyzed by Mann-Whitney U test.Fisher exact probability method was used to compare the group differences of categorical variables.P＜0.05 was considered statistically significant.Results There were 785 hospitalized patients with anti-SSA positivity.Among these,a total of 7 patients(0.89％)were diagnosed as MS.Fourteen MS patients with negative anti-SSA antibody were included with matched sex and age.There was a statistical significant difference in the frequency of positive antinuclear antibody(ANA)and anti-Ro-52 antibody between MS patients with positive anti-SSA antibody and those with negative anti-SSA(6/7 vs.0/14,P＜0.001;4/7 vs.0/14,P=0.006,respectively).No statistical significant difference in other clinical features was detected between the two groups(P＞0.05).Conclusion The frequency of ANA and anti-Ro-52 antibody positivity is significantly higher in MS patients with positive anti-SSA antibody.Our results suggest the presence of positive anti-SSA antibody has no affect on clinical features of MS.The relationship between MS and anti-SSA positivity may be incidently coexisted.
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