Objective To explore the causal association between inflammatory cytokines and fibromyalgia by Mendelian randomization analysis.Methods By mining the GWAS Catalog database and FinnGen database,the exposure factor was set as inflammatory cytokines,and the outcome was fibromyalgia.The main analysis method adopted in this study is inverse variance weighted(IVW)method,with MR-Egger,Simple Mode method,weighted median(WM),and Weighted Mode as supplementary statistical methods for Mendelian randomization analysis.Subsequently,by swapping the exposure factors and outcomes,the directionality of the analysis was tested.Results Among the 91 known inflammatory cytokines,a causal association was found between natural killer cell receptor 2B4(CD244),monocyte chemotactic protein 2(MCP-2),C-X-C chemokine 6(CXCL6),interleukin 12β subunit(IL12B),and fibromyalgia.Among them,CD244,CXCL6,and IL12B were positively correlated with FM[CD244:OR(95％CI)=1.21(1.08,1.35),P＜0.001].[MCP-2:OR(95％CI)=0.91(0.87,0.96),P＜0.001],[CXCL6:OR(95％CI)=1.15(1.06,1.24),P＜0.001],IL-12B[OR(95％CI)=1.13(1.06,1.20),P＜0.001].Sensitivity analysis did not find multiple effects,heterogeneity,or correlation.Conclusion The increase in the levels of CD244,CXCL6,and IL-12B will increase the risk of FM,while the increase in the level of MCP-2 will reduce the risk of FM disease.
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