Objective To explore the status of osteoporosis in patients with ankylosing spondylitis in the Han and four other ethnic minorities in Xinjiang.Methods From January 2019 to June 2020,89 patients with ankylosing spondylitis who were hospitalized in the Rheumatology and Immunology Department of the First Affiliated Hospital of Xinjiang Medical University with complete data were collected.Age,sex,body mass index,course of the disease,blood calcium,phosphorus,alkaline phosphatase,25 hydroxy-vitamin D3 level,C-reactive protein,erythrocyte sedimentation rate,human leukocyte antigen B27,family history,peripheral joint involvement were analyzed between Han and ethnic minority patients.Extra-articular manifestations,presence or absence of fracture,and bone mineral density were analyzed with SPSS 26.0.Quantitative data were described using s and independent sample t-test.Counting data was described using n(％)and Pearson x2 test.The rank sum test was used for econometric data and grade data that were not meet with normal distribution.Results Among the 89 patients,46 were Han and 43 were ethnic minorities,with an average age of(37.2±8.4)years.Seventeen patients had osteoporosis,of which 7 were Han and 10 were ethnic minorities.The mean age was(34.2±10.4)years.and the course of disease was(11.6±4.9)months.Among the patients with osteoporosis,the age of ethnic minority patients was younger[ethnic minority(25.4±10.7)years vs.Han(37.8±10.5)years,t=2.48,P=0.021],and the duration of disease was shorter(month)[ethnic minority(5.4±2.6)months vs.Han(8.5±2.0)months,t=2.63,P=0.015].Conclusion Although ankylosing spondylitis is mainly in young people,osteoporosis is not uncommon.Ethnic minority patients with ankylosing spondylitis complicated with osteoporosis are younger in age and shorter in course of disease than Han patients.
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