Objective To summarize the clinical characteristics in of different antibody subtypes in of patients with antisynthetase syndrome(ASS)complicated with interstitial lung disease(ILD).Methods A retrospective analysis was conducted on 132 ASS-ILD patients at the First Affiliated Hospital of Nanjing Medical University(Jiangsu Provincial People's Hospital),encompassing a period from December 2019 to June 2023.The data included were basic demographic information,clinical features,laboratory test results,chest computed tomography(CT)scans,and pulmonary lung function tests.Patients were categorized into distinct subtypes based on anti-aminoacyl tRNA synthetase(ARS)antibodies.Statistical analysis was performed using a t-test for comparing means between two samples with equal variance,the Mann-Whitney U test for non-normally distributed continuous data,and the chi-square(x2)test or Fisher's exact test for categorical variables.Results The most prevalent subtype of anti-synthetase antibody was anti-histidine antibody(Jo-1),accounting for 60 of 132 cases(45.5％),followed by anti-glycine-based tRNA synthetase antibody(EJ)(33/132,2 5.0％),anti-tRNA synthase antibody(PL-7)(26/132,19.7％),anti-alanine-based tRNA synthetase antibody(PL-12)(7.6％,10/132),anti-isoleucine-tRNA synthase antibody(OJ)(3/132,2.2％).The presence of anti-Ro-52 antibodies was significantly associated with rapidly progressive ILD.In patients with different subtypes of ASS-ILD,the presence of anti-Jo-1 antibodies is was positive in 28 cases(46.7％),and the combination of infection is was more common than in other groups(x2=0.15,P=0.047).The group with positive anti-EJ antibodies has had a significant decline in lung function,and cough is was more common in 31 cases(93.9％)than in other groups(P＜0.05);the group with positive anti-PL-12 antibodies has had a more pronounced decline in lung function than other groups(P＜0.05),and fever(7 cases,70.0％)wais more common than in other groups(x2=0.02,P=0.022).Conclusion Anti-Jo-1,Anti-PL-7,and Anti-PL-12 antibodies were are observed more frequently in patients with ILD.Furthermore,a significant deterioration in lung function was is observed in patients testing positive for anti-PL-12 and anti-EJ antibodies.
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