Objective To analyze the clinical characteristics and influencing factors of vascular involvement in Behçet's Disease(BD)to improve and provideunderstanding of insights for clinicians to better understand this condition.Methods Clinical data from 220 BD patients admitted to the First Affiliated Hospital of Guangxi Medical University from January 2012 to May 2022 were collected.Clinical manifestations and laboratory findings were compared between BD patients with and without vascular involvement,as well as between those with improved conditions and those with progressive conditions.Binary logistic regression was used to analyze the influencing factors.Results ①The average age of the 220 BD patients was 36.5±15.3 years.Among them,23 patients(10.5％)had vascular involvement,including 20 males(87.0％).②Compared to BD patients without vascular involvement,those with vascular involvement had significantly higher rates of smoking[6.1％(12/197)vs.34.8％(8/23),x2=17.19,P＜0.001],cardiac involvement[1.5％(3/197)vs.13.0％(9/23),x2=6.42,P=0.011],and elevated C-reactive protein(CRP)levels(78.3％vs.56.3％,x2=4.08,P=0.043).③ Among BD patients with vascular involvement,11 cases(47.8％)had venous lesions,and 20 cases(87.0％)had arterial lesions,with 8 cases(34.8％)having both venous and arterial involvement.The most common type of vascular involvement was arterial dilatation(11 cases),mainly aneurysms(10 cases),and deep venous thrombosis of the lower extremities(7 cases).④The 23 BD patients with vascular involvement were followed up for an average of 18.3 months.Among them,16 patients(69.6％)showed stable improvement,while 7 patients(30.4％)experienced disease progression,including 4 deaths(1 male and 3 females).A total of 91.3％(21/23)of the patients received glucocorticoid therapy.Immunosuppressive therapy was administered to 82.6％(19/23)of the patients,with 65.2％(10/23)receiving with cyclophosphamide and 43.5％receiving with thalidomide.Additionally,13％(3/23)of the patients were treated with cyclosporine and methotrexate,respectively,and 8.7％(2/23)were treated with received mycophenolate mofetil.Anticoagulant therapy was given to 21.7％(5/23)of the patients,using either warfarin or low molecular weight heparin.Biologic therapy was administered to 17.4％(4/23)of the patients,and surgical intervention was performed in 43.5％(10/23)of the patients.⑤Binary logistic regression analysis identified male gender[OR(95％CI)=5.70(1.60,20.90),P=0.009]as an indepe-ndent risk factor for vascular involvement in BD.Conclusion The incidence of vascular involvement in BD is 10.5％,with a higher prevalence in males.Arterial involvement is more common than venous involvement,with arterial aneurysms being the most common manifestation.Clinicians should pay attention to CRP and total cholesterol levels in BD patients.
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