摘要
目的 调查新疆地区塔吉克族、柯尔克孜族、汉族健康人群ANA、抗dsDNA抗体的阳性率及高滴度情况.方法 选取3687名塔吉克族居民、2 140名柯尔克孜族居民、2034名汉族居民为研究对象,分别检测ANA、抗dsDNA抗体并作对比分析.数据分析使用SPSS 22.0软件,采用x2检验.结果 塔吉克族组ANA阳性率为 15.1％(555/3 687)[其中男性 10.2％(147/1 445),女性 18.2％(408/2 242)],其中高滴度占 25.8％(143/555);柯尔克孜族组为 16.7％(357/2 140)[男性 10.3％(101/980),女性 19.4％(256/1 160)],高滴度占 14.8％(53/357);汉族组阳性率 16.6％(337/2 034)[男性9.8％(70/720),女性 19.1％(267/1 314)],高滴度占 18.4％(62/337).3个民族间ANA阳性率差异无统计学意义(x2=3.64,P=0.162),但塔吉克族ANA高滴度比例较汉族、柯尔克孜族存在差异(25.8％和18.4％,x2=6.02,P=0.014;25.8％和14.8％,x2=14.71,P=0.001),占比偏高.3组中ANA高滴度人群均是51～60岁年龄段最多.塔吉克族和柯尔克孜族高滴度人群ANA核型占比最多的是颗粒型,汉族则是均质型.塔吉克族组抗dsDNA抗体阳性率为0.71％(26/3 687),其中高滴度占23.1％(6/26);柯尔克孜族组为0.75％(16/2034),高滴度占31.3％(5/16);汉族组阳性率为0.69％(14/2034),其中高滴度占28.6％(4/14),3组间抗dsDNA抗体阳性率及高滴度比例差异均无统计学意义(x2=0.06,P=0.972;x2=0.37,P=0.832).结论 本研究中新疆地区民族间ANA和抗dsDNA抗体及高滴度占比不尽相同,需长期随访,关注自身抗体高滴度人群自身免疫病的发病情况.
Abstract
Objective To investigate the positivity rate and high titer of antinuclear antibody(ANA)and anti-dsDNA antibody in healthy Tajik,Kirgiz,and Han Chinese populations in Xinjiang.Methods A total of 3 687 cases of Tajik residents,2 140 cases of Kyrgyz residents,and 2 034 cases of Han residents were selected as the study subjects,and ANA and anti-dsDNA antibodies were detected and comparatively analyzed.Data were analyzed using SPSS 22.0 software with x2 test.Results The positive rate of ANA in Tajik group was 15.1％[(555/3 687),10.2％(147/1 445)male,18.2％(408/2 242)female],of which high titers accounted for 25.8％(143/555).It was 16.7％(357/2 140)in the Kyrgyz group[10.3％male(101/980),19.4％(256/1 160)female],with high titers accounting for 14.8％;and in the Han group,the positivity rate was 16.6％[9.8％(70/720)male,19.1％(267/1 314)female],with high titers accounting for 18.4％(62/1 337).There was no significant difference in ANA positivity rate among the three ethnic groups(x2=3.64,P=0.162),but there were differences in the percentage of high titer of ANA in Tajik ethnic group compared with Han and Kyrgyz ethnic groups(25.8％vs.18.4％,x2=6.02,P=0.014;25.8％vs.14.8％,x2=14.71,P=0.001),which accounted for a high percentage.The highest number of ANA high titers in all three groups was in the age group of 51～60 years.The ANA karyotype with the highest percentage of high titers in the Tajik and Kyrgyz populations was granular,while it was homogeneous and in the Han it was homogeneous.The positive rate of anti-dsDNA antibody in the Tajik group was 0.71％(26/3 687),of which high titer accounted for 23.1％(6/126);in the Kyrgyz group,it was 0.75％(16/2 034),and high titer accounted for 31.3％(4/14);and in the Han group,the positive rate was 0.69％(14/2 034),of which high titer accounted for 28.6％(4/64),and there was no statistical significance of in the difference in the positive rate of anti-dsDNA antibody and the proportion of high titer among the three groups(x2=0.06,P=0.972;x2=0.37,P=0.832).Conclusion The percentage of ANA and anti-dsDNA antibodies and high titers varied vary among the three ethnic groups in this study,and long-term follow-up is needed to monitor keep an eye on the incidence of autoimmune diseases in people with high autoantibody titers.
基金项目
新疆维吾尔自治区重点研发项目(2022B03002-1)
NETL
NSTL
万方数据