衰老相关分泌表型引起的早衰在电离辐射诱导血管内皮细胞损伤中的作用
Role of senescence-associated secretory phenotype-related premature senescence in ionizing radiation-induced damage to vascular endothelial cells
伊如罕 1刘萌萌 1陈婕 1李辰 1高玲 1刘青杰1
作者信息
- 1. 中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室,北京 100088
- 折叠
摘要
辐射诱发的血管内皮损伤是放疗的主要并发症,也是事故受照人群发病和死亡的主要原因.电离辐射诱导的细胞衰老是导致血管内皮细胞损伤的重要因素,因此深入理解衰老相关分泌表型(SASP)导致早衰的机制及其在电离辐射诱导血管内皮细胞损伤中的作用,对预防及治疗电离辐射诱发血管内皮细胞损伤具有重要意义.本文从电离辐射诱导的血管内皮细胞损伤机制、电离辐射诱导细胞早衰以及SASP相关早衰在电离辐射诱导血管内皮细胞损伤中的作用及潜在靶点3个方面进行综述,探讨SASP相关早衰与电离辐射诱导血管内皮细胞损伤的关系.
Abstract
Radiation-induced damage to vascular endothelium is a major complication of radiotherapy and a primary cause of morbidity and mortality in the population exposed to radiation.Ionizing radiation-induced cellular senescence serves as a critical factor in damage to vascular endothelial cells.Therefore,understanding the mechanisms of cellular senescence caused by senescence-associated secretory phenotype(SASP),as well as its role in ionizing radiation-induced damage to vascular endothelial cells,is significant for preventing and treating ionizing radiation-induced damage to vascular endothelial cells.In this study,the relationship between SASP-related premature senescence and this ionizing radiation-induced damage was explored from the following aspects:the mechanisms behind ionizing radiation-induced damage to vascular endothelial cells,ionizing radiation-induced cellular senescence,and the role of SASP-related premature senescence in the ionizing radiation-induced damage to vascular endothelial cells,as well as potential targets.
关键词
衰老相关分泌表型(SASP)/细胞早衰/血管内皮细胞/电离辐射Key words
Senescence-associated secretory phenotype(SASP)/Cellular senescence/Vascular endothelial cell/Ionizing radiation引用本文复制引用
基金项目
北京市自然科学基金(7162139)
北京市自然科学基金(7202137)
国家自然科学基金(31570852)
出版年
2024
NETL
NSTL
万方数据