Role of senescence-associated secretory phenotype-related premature senescence in ionizing radiation-induced damage to vascular endothelial cells
Radiation-induced damage to vascular endothelium is a major complication of radiotherapy and a primary cause of morbidity and mortality in the population exposed to radiation.Ionizing radiation-induced cellular senescence serves as a critical factor in damage to vascular endothelial cells.Therefore,understanding the mechanisms of cellular senescence caused by senescence-associated secretory phenotype(SASP),as well as its role in ionizing radiation-induced damage to vascular endothelial cells,is significant for preventing and treating ionizing radiation-induced damage to vascular endothelial cells.In this study,the relationship between SASP-related premature senescence and this ionizing radiation-induced damage was explored from the following aspects:the mechanisms behind ionizing radiation-induced damage to vascular endothelial cells,ionizing radiation-induced cellular senescence,and the role of SASP-related premature senescence in the ionizing radiation-induced damage to vascular endothelial cells,as well as potential targets.
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