snoRNA在电离辐射诱导的DNA损伤中的作用及研究进展
Role and research progress of snoRNAs in ionizing radiation-induced DNA damage
邓佳荣 1张文成 2沈丽萍 2王治东1
作者信息
- 1. 南华大学衡阳医学院军事科学院研究生协作培养基地,衡阳 421001;军事科学院军事医学研究院辐射医学研究所放射生物学研究室,北京 100850
- 2. 军事科学院军事医学研究院辐射医学研究所放射生物学研究室,北京 100850
- 折叠
摘要
核仁小RNA(small nucleolus RNA,snoRNA)是一类在真核生物中普遍存在的非编码RNA,根据其结构特征,可分为两大类:box C/D snoRNA和box H/ACA snoRNA,分别介导RNA2'-O-甲基化和假尿嘧啶化修饰.近期研究发现,snoRNA还影响mRNA前体(pre-mRNA)的可变剪接,能够通过生成miRNA来介导基因沉默,并通过与蛋白质相互作用调节其功能活性.在电离辐射的生物效应中,DNA损伤与修复过程是至关重要的生物学基础.然而,目前关于snoRNA在电离辐射引起的DNA损伤中的作用的研究还相当有限.本综述旨在概述snoRNA的生物学功能及其在电离辐射诱导的DNA损伤修复中可能的调控角色,以期为探究snoRNA的功能及机制提供新思路.
Abstract
Small nucleolar RNAs(snoRNAs),a type of non-coding RNAs ubiquitous in eukaryotes,can be categorized into two types based on structural characteristics:box C/D snoRNAs and box H/ACA snoRNAs,which mediate the RNA modification of 2'-O-methylation and pseudouridylation,respectively.Recent studies have found that snoRNAs also affect the alternative splicing of mRNA precursors(pre-mRNA),mediate gene silencing by generating miRNA,and interact with proteins to regulate their functional activity.The process of DNA damage and repair always serves as a pivotal biological basis in research on the biological effects of ionizing radiation.Currently,there are rather limited studies on the role of snoRNAs in ionizing radiation-induced DNA damage.Thus,this paper reviews the biological functions of snoRNAs and their potential role in the regulatory repair of ionizing radiation-induced DNA damage,with a view to providing new ideas for exploring the function and mechanism of snoRNAs.
关键词
核仁小RNA/电离辐射/DNA损伤反应Key words
Small nucleolus RNA/Ionizing radiation/DNA damage response引用本文复制引用
基金项目
国家自然科学基金面上项目(32071240)
出版年
2024
NETL
NSTL
万方数据