Role and research progress of snoRNAs in ionizing radiation-induced DNA damage
Small nucleolar RNAs(snoRNAs),a type of non-coding RNAs ubiquitous in eukaryotes,can be categorized into two types based on structural characteristics:box C/D snoRNAs and box H/ACA snoRNAs,which mediate the RNA modification of 2'-O-methylation and pseudouridylation,respectively.Recent studies have found that snoRNAs also affect the alternative splicing of mRNA precursors(pre-mRNA),mediate gene silencing by generating miRNA,and interact with proteins to regulate their functional activity.The process of DNA damage and repair always serves as a pivotal biological basis in research on the biological effects of ionizing radiation.Currently,there are rather limited studies on the role of snoRNAs in ionizing radiation-induced DNA damage.Thus,this paper reviews the biological functions of snoRNAs and their potential role in the regulatory repair of ionizing radiation-induced DNA damage,with a view to providing new ideas for exploring the function and mechanism of snoRNAs.
Small nucleolus RNAIonizing radiationDNA damage response
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