Advances in application of organoids to research on radiotherapy of tumors
Organoids are in vitro-cultured three-dimensional(3D)miniature structures derived from human pluripotent stem cells or adult stem cells from healthy individuals or patients.Compared to traditional two-dimensional(2D)cell lines or animal models,organoids are regarded as more promising high-fidelity models,possessing unique advantages in terms of disease modeling,drug development,the establishment of living biobanks,and the exploration of personalized treatment.Over recent years,the rapid development of organoid technology has brought new hopes for innovating preclinical experimental tumor models and promoting clinical personalized diagnosis and treatment.This review is intended to introduce the development status and latest progress of organoids in the field of radiotherapy for tumors,explore the advantages and limitations of organoid models for cancer,and prospect for its application in the field of radiotherapy.
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维普
