Research progress on the ionizing radiation-induced mutational signatures
In the past decade,high-throughput sequencing technologies have generated a massive amount of genomic mutation data.The interpretation of mutation data from tumor samples has revealed mutational features highly associated with carcinogenic factors,which are referred to as mutational signatures.These mutational signatures enable the assessment of the contribution rates of various carcinogenic factors during the multi-stage development of tumors.Ionizing radiation-induced gene mutations constitute the molecular basis for its carcinogenic effects.Clarifying the patterns of mutational signatures induced by ionizing radiation is of great importance for a profound understanding of stochastic effects.This review presents the research history and analytical method of mutational signatures as well as a comprehensive summary of the current status of research on mutational signatures induced by ionizing radiation.The future development of this field is also discussed.
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