Measurement of external radiation levels around patients treated with 177Lu-DOTA-TATE and preliminary estimation of doses to the surrounding personnel
Objective To investigate the decay law of 177Lu-DOTA-TATE in the treatment of neuroendocrine tumors in patients with external radiation and the radiation dose to the surrounding persons.Methods The radiation dose rate from patients to the surrounding environment after 177Lu-DOTA-TATE treatment was measured using a handheld radiation dosimeter at different times.The decay law of the radiation dose rate with time and distance was analyzed,and the radiation levels at different distances from the patients and the radiation dose of the patients to the surrounding persons were estimated.Results The external radiation dose rate from the patients decayed exponentially with time rapidly in the early stage and gradually slowly in the later stage.The effective half-life was(1.41±0.25)h(0.9-1.8)h in the rapid decay stage and(40.18±6.0)h(32.7-54.73 h)in the slower decay stage.At 0 h after injection,the normalized mean radiation dose rates at 0.25,0.5,1,2,and 3 m away from the patient were 41.7±6.3,20.0±3.0,7.2±3.8,3.4±0.9,and 1.9±0.4 µSv·h-1·GBq-1,respectively.The radiation doses to doctors,nurses,physicists,and positioning technicians were 2.0,10.24,1.08,and 4.05 µSv/patient,respectively.Conclusions The external radiation dose rate from patients receiving 177Lu-DOTA-TATE treatment rapidly decreases over time and distance.The radiation levels that patients may cause to the surrounding workers are within the allowable range of national standards.After discharge,patients should reduce close and long-term contact with the surrounding persons.
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