Objective To analyze the risk factors of biliary infection after endoscopic retrograde cholangiopancreatography(ERCP)in patients with malignant biliary obstruction.Methods Clinical data of 160 patients with malignant biliary obstruction admitted to the Affiliated People's Hospital of Ningbo Univer-sity from June 2017 to June 2022 were retrospectively analyzed,including 89 males and 71 females,aged(65.1±8.0)(range,41-78)years old.Patients were divided into two groups according to the occurrence of biliary infection within 30 days after ERCP:infected group(n=30)and uninfected group(n=130).Multivariate logistic regression was used to identify the risk factors of postoperative biliary infection.Results The incidence of biliary infection after ERCP was 18.8％(30/160)in the patients with malignant biliary obstruction.A total of 43 strains of pathogenic bacteria were detected,including 34 Gram-negative strains and nine Gram-positive strains.The most common pathogenic bacterium was Escherichia coli.Multivariate analysis showed patients with diabetes mellitus(OR=2.356,95％CI:1.587-5.441,P=0.001),sphincter dysfunction(OR=2.651,95％CI:1.854-6.225,P=0.005),preoperative albumin＜35 g/L(OR=3.225,95％CI:2.041-5.689,P=0.002),preoperative hemoglobin＜110 g/L(OR=3.424,95％CI:2.115-6.333,P=0.003)suffered a higher risk of biliary infection after ERCP.Conclusion Diabetes mellitus,sphincter dysfunction,lower levels of preoperative albumin and hemoglobin are independent risk factors for biliary infection after ERCP in patients with malignant biliary obstruction.
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