Primary liver cancer is a malignant tumor with high morbidity and mortality.It also ranks in the forefront in the incidence and mortality of malignant tumors in China,which seriously threatens the lives and health of Chinese people.Most patients have already been in the intermediate and late stage when they are diagnosed,thus the chance of surgery is lost,and the prognosis is poor.In recent years,with the advancement of vascular interventional therapy technologies such as hepatic arterial chemoembolization and hepatic arterial infusion chemotherapy,the emergence of new tyrosine kinase inhibitors,immune checkpoint inhibitors,and especially the development of multimodal combination therapy,the treatment effect of unre-sectable hepatocellular carcinoma has been continuously improved,and it also provides a potential possibility for sequential surgical treatment.This article reviews the research progress of vascular interventional therapy combined with systemic therapy in unresectable hepatocellular carcinoma,in order to provide a reference for the clinical treatment of unresectable hepatocellular carcinoma.
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