Objective To evaluate the relationship between red blood cell distribution width(RDW)and prognosis of patients with hepatocellular carcinoma(HCC)andergoing transcatheter arterial chemoembolization(TACE).Methods Clinical data of 212 patients with HCC andergoing TACE for the first time in Department of Interventional Radiology,the Affiliated Hospital of Xuzhou Medical University from January 2011 to May 2018 were retrospectively analyzed,including 184 males and 28 females,aged(56.8±11.2)years.Follow-up for survival.X-tile software was used to determine 13.1％as the optimal threshold for preoperative RDW prediction of prognosis,and enrolled patients were divided into a low level group(RDW＜13.1％,n=70)and a high level group(RDW≥ 13.1％,n=142).Aspartate aminotrans-ferase,total bilirubin,albumin,hemoglobin and lipoprotein a,Barcelona clinical liver cancer(BCLC)stage and other indexes were compared between the two groups.Survival analysis was performed by Kaplan-Meier method,survival rate was compared by log-rank test,and the effect of RDW on prognosis was analyzed by Cox regression.Results The 1-year,2-year and 3-year cumulative survival rates in RDW high level group were 34.5％,14.1％and 6.3％,respectively,while those in RDW low level group were 64.3％,38.6％and 21.4％,respectively,with significant difference(x2=23.09,P＜0.001).Compared with the low level group,the levels of aspartate aminotransferase and total bilirubin were higher,the levels of albu-min,hemoglobin and lipoprotein a were lower,the proportion of portal vein cancer thrombin was higher,and the stage of BCLC was later,with statistical significance(all P＜0.05).Cox regression analysis showed that HCC patients with RDW≥13.1％(HR=1.732,95％CI:1.223-2.452,P=0.002)had poor survival prognosis after TACE.Conclusion Preoperative RDW≥13.1％is an independent risk factor for survival after TACE in patients with HCC.RDW has potential predictive value for prognosis of patients with HCC.
Carcinoma,hepatocellularChemoembolization,therapeuticPrognosisRed blood cell distribution width
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