程序性死亡蛋白1及其配体作为肝移植术后免疫耐受标志物的研究进展
Research progress on programmed death 1 and its ligand as markers of immune tolerance after liver transplantation
李宏宇 1陈璐 1陈敬2
作者信息
- 1. 天津中医药大学测试中心,天津 301617
- 2. 天津中医药大学第二附属医院皮肤科,天津 300250
- 折叠
摘要
程序性死亡蛋白1(PD-1)/PD-1配体(PD-L1)是介导免疫抑制的重要信号分子,该通路导致肿瘤细胞逃避机体免疫监视,对于抗肿瘤免疫产生不利影响.而对于移植物来说,PD-1/PD-L1信号通路的激活在移植物躲避免疫细胞攻击,形成免疫耐受中发挥重要作用.已有研究显示PD-1/PD-L1为角膜移植、心脏移植和肺移植免疫耐受的监测提供了可靠依据,但对于评估肝脏移植后的免疫状态并未作出详细阐述.本文就PD-1/PD-L1成为肝移植术后免疫耐受标志物的潜在可能性进行综述.
Abstract
Programmed death 1(PD-1)/PD-1 ligand(PD-L1)are important signaling molecules that mediate immunosuppression.This signaling pathway leads to the evading of tumor cells from immune surveillance and plays an adverse affect on anti-tumor immunity.For grafts,the activation of PD-1/PD-L1 signaling pathway also plays an important role in the its evasion from host immune attack and the formation of immune tolerance.PD-1/PD-L1 has been shown to regulate immune tolerance in corneal,heart and lung transplantation.Its role in liver transplantation,however,has yet to be elaborated.This article reviews the potential of PD-1/PD-L1 as a marker of immune tolerance after liver transplantation.
关键词
肝移植/程序性细胞死亡受体1/程序性细胞死亡配体1/免疫耐受/生物标志物Key words
Liver transplantation/Programmed cell death 1 receptor/Programmed cell death ligand 1/Immune tolerance/Biological marker引用本文复制引用
出版年
2024
NETL
NSTL
万方数据