外泌体非编码RNA在胰腺疾病中的作用
Role of exosomal non-coding RNA in pancreatic diseases
李姗姗 1牟作 1李满 1余佳1
作者信息
- 1. 武汉大学人民医院肝胆外科,武汉 430060
- 折叠
摘要
外泌体是一种细胞外囊泡,其通过介导蛋白质、核酸、脂质的释放参与调控机体各种信号通路,从而在炎症、肿瘤、免疫、神经系统等病理生理过程中发挥着重要的作用.越来越多的研究表明,外泌体非编码RNA(ncRNA)在胰腺疾病中发挥着重要作用,本文从外泌体ncRNA出发,综述其在急性胰腺炎、胰腺癌等胰腺疾病的发生、诊断与治疗中的作用,以期为临床提供参考.
Abstract
Exosomes are extracellular vesicles that regulate various signaling pathways in the body by mediating the release of proteins,nucleic acids and lipids,thus playing an important role in pathophysio-logical processes such as inflammation,tumor,immunity and nervous system.More and more studies have shown that exosomal non-coding RNA(ncRNA)plays a crucial role in pancreatic diseases.This article reviews the role of exosome ncRNA in the occurrence,diagnosis and treatment of pancreatic diseases such as acute pancreatitis and pancreatic cancer,in order to provide a reference for clinical practice.
关键词
外泌体/非编码RNA/急性胰腺炎/胰腺癌Key words
Exosomes/Non-coding RNA/Acute pancreatitis/Pancreatic carcinoma引用本文复制引用
基金项目
国家自然科学基金(82003063)
武汉市中青年医学骨干人才培养项目(武卫生计生201659号)
出版年
2024
NETL
NSTL
万方数据