肝内胆管癌的多组学研究进展
Research progress on the multi-omics of intrahepatic cholangiocarcinoma
康美清 1吴忠均 1廖锐1
作者信息
- 1. 重庆医科大学附属第一医院肝胆外科,重庆 400016
- 折叠
摘要
肝内胆管癌(ICC)是肝内第二常见的原发恶性肿瘤,起病隐匿,病死率高.近年来高通量测序技术被广泛应用于ICC的多组学研究,不仅发现了许多新的致病机制,还为ICC的分层分型、预后评估以及临床综合治疗提供了依据.本文综述ICC在基因组学、表观组学、转录组学、蛋白质组学、代谢组学、单细胞测序组学及整合组学中的研究进展,为ICC的临床诊疗提供参考.
Abstract
Intrahepatic cholangiocarcinoma(ICC)is the second most common primary neoplasm in the liver,with insidious clinical symptoms and high mortality rate.In recent years,high-throughput sequen-cing technologies have been widely used in the multi-omics research of ICC,which not only promote the dis-covery of some new pathogenic mechanisms,but also provide a profound basis for the stratified classification,prognosis assessment and clinical comprehensive treatment strategy of this lethal tumor.This review focuses on the progress of ICC in genomics,epigenomics,transcriptomics,proteomics,metabolomics,single-cell sequencing omics and integrative omics,and provides ideas for the diagnosis and treatment of this tumor.
关键词
胆管上皮癌/多组学研究/肿瘤微环境/分子表型Key words
Cholangiocarcinoma/Multi-omics/Tumor microenvironment/Molecular pheno-type引用本文复制引用
基金项目
国家自然科学基金(82170666)
重庆市自然科学基金(CSTB2022NSCQ-MSX0112)
重庆医科大学未来医学青年创新团队(W0087)
出版年
2024
NETL
NSTL
万方数据