不可切除肝细胞癌转化治疗的研究进展
Advances in conversion therapy of unresectable hepatocellular carcinoma
谭逢武 1许达峰 1郑进方1
作者信息
- 1. 海南医学院附属海南医院(海南省人民医院)肝胆胰外科,海口 570311
- 折叠
摘要
原发性肝癌是我国主要的恶性肿瘤之一,发病率高且预后差,多数患者确诊时已处于中晚期,无法行根治性手术.随着转化治疗的出现和不断发展,中晚期不可切除肝癌成功转化为可手术切除,患者生存期显著改善.目前,临床上转化治疗方案主要包括了局部治疗、系统治疗及二者的联合治疗.本文对初始不可切除肝细胞癌转化治疗的方案、治疗后手术指征和手术时机及术后辅助治疗等多方面进行探讨和展望.
Abstract
Primary liver cancer is one of the prevalent malignant neoplasm in China,characterized by a high incidence rate and a dismal prognosis.Upon diagnosis,the majority of patients have progressed to an advanced or intermediate stage,rendering radical surgery impracticable.With the advent and ongoing advancement of translational therapy,the prognosis of patients with middle-to late-stage unresectable hepato-cellular carcinoma has been substantially enhanced through the successful conversion of this disease from unresectable to surgically resectable.At present,the primary clinical treatment options for transformative conditions consist of local therapy,systemic therapy,or a combination of the two.This article examines and anticipates the diverse facets of the conversion treatment options for initial unresectable hepatocellular carci-noma,surgical indications and timing following treatment,and postoperative adjuvant therapy.
关键词
肝肿瘤/外科手术/转化治疗/联合治疗Key words
Liver neoplasms/Surgical procedures,operative/Conversion therapy/Combina-tion therapy引用本文复制引用
基金项目
国家自然科学基金(82160472)
海南省重点研发计划(ZDYF2022SHFZ131)
海南省临床医学研究中心项目(LCYX202208)
出版年
2024
NETL
NSTL
万方数据