肝内胆管癌治疗的研究进展
Research progress in the treatment of intrahepatic cholangiocarcinoma
陈超波 1张硕 2周琰 2仇毓东2
作者信息
- 1. 江苏省无锡市锡山人民医院普外科,无锡 214105
- 2. 南京大学医学院附属鼓楼医院普外科,南京 210008
- 折叠
摘要
肝内胆管癌(ICC)是肝脏胆管上皮细胞来源的恶性肿瘤.根治性手术被认为是当前唯一可能治愈的方案,但是预后仍不理想.随着肿瘤免疫治疗的研究进展,化疗联合免疫治疗可提高ICC患者的生存率,已成为一线方案.基于基因组学的靶向治疗能使部分基因突变的ICC患者获益.另外,全身联合局部治疗也能改善部分ICC患者的预后.尽管如此,对ICC的治疗依然困难重重.本文对ICC治疗的策略作一综述,旨在为临床诊疗和基础研究提供有价值的参考.
Abstract
Intrahepatic cholangiocarcinoma(ICC)is a malignant tumor derived from the biliary epithelial cells of the liver.Radical surgical resection remains the only potentially curative treatment but still with a dismal prognosis.In light of research progress in tumor immunotherapy,the combination of chemo-therapy and immunotherapy has recently emerged as a first-line regimen for a significantly improved survival in patients with ICC.Genomics-based targeted therapy can benefit ICC patients with specific gene mutations.Additionally,systemic combined with local treatment can also benefit a group of patients with ICC.The management of ICC remains challenging and we hereby reviewed the treatment strategies of ICC to provide valuable references for clinical diagnosis,treatment,and basic research of ICC.
关键词
胆管上皮癌/手术切除/淋巴清扫/局部治疗/靶向治疗/免疫疗法Key words
Cholangiocarcinoma/Surgical resection/Lymph node dissection/Local treat-ment/Targeted therapy/Immunotherapy引用本文复制引用
基金项目
国家自然科学基金(31971518)
江苏省卫健委重点项目(ZD2021017)
无锡市卫生健康委中青年拔尖人才资助计划(HB2023116)
出版年
2024
NETL
NSTL
万方数据