Clinical efficacy of sequential PTCD and primary closure of common bile duct after laparoscopic common bile duct exploration in treatment of choledocholithiasis complicated with moderate and se-vere acute cholangitis
Objective To study the clinical efficacy of percutaneous transhepatic cholangial drain-age(PTCD)and primary closure of common bile duct after laparoscopic common bile duct exploration(LCBDE)in treatment of choledocholithiasis complicated with moderate and severe cholangitis.Methods The clinical data of 127 patients with choledocholithiasis complicated with acute cholangitis admitted to Yan-tai Affiliated Hospital of Binzhou Medical University from January 2021 to August 2023 were retrospectively analyzed.Finally,45 patients were enrolled,including 20 males and 25 females,aged(71.3±8.2)years.All 45 patients were treated with sequential PTCD and primary closure of common bile duct after LCBDE.The interval from PTCD to primary closure,white blood cell count,total bilirubin,alanine transaminase before and after PTCD,operation time of primary closure,intraoperative blood loss,postoperative retention time of abdominal drainage tube,postoperative hospitalization time,postoperative complications(bile leak-age,bleeding,etc.)were analyzed.Results The serum total bilirubin,alanine transaminase and white blood cell count of 45 patients were(143.2±32.1)μmol/L,(173.6±23.4)U/L,(16.3±2.9)×109/L at admission,and(100.5±21.4)μmol/L,(103.5±12.7)U/L,(8.6±1.7)×109/L after PTCD,respectively.The interval between PTCD and primary closure of common bile duct after LCBDE was(4.3±1.1)d,the operative time of primary closure was(123.4±20.5)min,the amount of intraoperative blood loss was(32.6±8.7)ml.The postoperative hospitalization time was(6.8±1.6)d,and the postoperative retention time of abdominal drainage tube was(4.5±1.3)d,and postoperative complications occurred in 7 cases(15.6％),including biliary leakage in 4 cases(8.9％),subxiphoid incision infection in 1 case(2.2％),and effusion in gallbladder fossa with infection in 2 cases(4.4％).Conclusion The sequential application of PTCD and primary closure of common bile duct after LCBDE in treatment of choledocholithiasis complicated with moderate and severe cholangitis is a safe,effective and minimally invasive method,and primary closure of common bile duct after LCBDE is safe and reliable within 1 week after PTCD.
CholedocholithiasisCholangitisCommon bile duct explorationPercutaneous transhepatic cholangial drainagePrimary closure
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NSTL
万方数据
