基于损伤模式建立肝再生小鼠模型的研究进展
Research progress in animal models of liver regeneration based on the different injury modalities
邱倩 1张慧 1尹贺贺 1徐洪海1
作者信息
- 1. 安徽医科大学第一附属医院病理科,合肥 230022
- 折叠
摘要
肝脏是一种具有出色再生潜力的实性器官,其再生能力与肝脏疾病密切相关.深入研究肝再生的机制对于理解肝脏生物学和发展再生医学具有重要意义.小鼠凭借其技术、经济及解剖学等优势成为当前最优候选动物.目前已有的肝再生小鼠模型包括部分肝切除、化学药物损伤模型和基因工程模型等,本综述比较其优缺点及应用前景,为后续研究提供参考.
Abstract
The liver is a solid organ with excellent regenerative potential.Its regenerative ability is closely related to liver disease.In-depth study of the mechanism of liver regeneration is of great significance for understanding liver biology and developing regenerative medicine.The mouse has been the most widely used animal model of liver regeneration for its technical,economic and anatomical advantages.The current mouse models of liver regeneration include partial liver resection,chemical drug injury,and genetic engi-neering models.In this review,we compared their advantages,shortcomings and application prospects to provide reference for future research.
关键词
肝切除术/肝再生/肝损伤/化学药物/基因工程/临床介入治疗Key words
Hepatectomy/Liver regeneration/Liver injury/Chemical drug/Gene editing/Clinical intervention therapy引用本文复制引用
基金项目
安徽省教育厅省高校科研重点项目(2022AH051182)
安徽省转化医学研究院科研基金(2023zhyx-C55)
安徽医科大学研究生科研与实践创新项目(YJS20230070)
出版年
2024
NETL
NSTL
万方数据