Ferroptosis is a kind of programmed cell death,involves multi-molecular and multi-signa-ling pathways,and the core processes is iron overload and lipid peroxidation.It affects cancer,neurological disease,cardiovascular disease,digestive system disease,and many other diseases.While,ischemia-reper-fusion injury is an extremely complex pathological process,including ischemia-reperfusion injury of the heart,brain,liver and kidney,etc.,which often occurs in shock,organ surgery and organ transplantation,seriously affecting human health,and there is no effective radical treatment.However,ferroptosis is closely related to ischemia-reperfusion injury so that it is possible to find the prevention and treatment measures of ischemia-reperfusion injury by exploring the internal relationship between them.Therefore,the author tries to summarize the signaling pathways of ferroptosis,and explores the relationship between ferroptosis and ische-mia-reperfusion injury of heart,brain,liver and kidney by moderating the ferroptosis targets properly to find the effective ways to treat cancer,improve inflammation and relieve other diseases.
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