Objective To study the predictive role of tumor burden score(TBS)for tumor recur-rence after radical resection in patients with hepatocellular carcinoma(HCC).Methods Clinical data of 202 patients with HCC undergoing radical surgery at the 900th Hospital of Joint Logistics Support Force of the Chinese People's Liberation Army,between January 2015 and December 2017 were retrospectively analyzed,including 128 males and 74 females,aged(53.66±11.93)years old.The receiver operating characteristic(ROC)curve was used to assess the accuracy of TBS in predicting postoperative tumor recurrence.Univari-ate and multivariate logistic regression analyses were performed to identify independent risk factors influen-cing postoperative tumor recurrence.A nomogram was established and validated using calibration curves and the C-index.Kaplan-Meier survival analysis was utilized to compare survival differences between the two patient groups.Results The area under the ROC curve for TBS in predicting postoperative tumor recurrence in HCC patients was 0.779(95％CI:0.717-0.842),with an optimal cutoff value of 6.2.Univariate analysis revealed that factors such as hepatitis B virus DNA level＞500 IU/ml,larger maximum tumor dia-meter,and TBS＞6.2 were significant risk factors for postoperative tumor recurrence(all P＜0.05).Multi-variate analysis further indicated that TBS＞6.2(OR=3.60,95％CI:1.081-12.012,P=0.037)and maximum tumor diameter(OR=1.240,95％CI:1.034-1.487,P=0.020)were independent risk factors for postoperative recurrence.Based on these risk factors,a nomogram model was established,achieving a C-index of 0.788.Kaplan-Meier survival analysis showed a better postoperative overall survival and recurrence-free survival of the low TBS group compared to those of the high TBS group(all P＜0.05).Conclusion TBS can serve as a predictive indicator for the recurrence after radical resection in patients with HCC.Both TBS and tumor size are independent risk factors for postoperative recurrence.The nomogram model can be used for predicting recurrence following radical resection in HCC patients.
维普
万方数据