Objective To compare the effects of drug-loaded microsphere TACE(D-TACE)and iodinated oil emulsion TACE(cTACE)on liver fibrosis in the treatment of advanced hepatocellular carcinoma(HCC).Methods Clinical data of 113 patients with HCC treated with D-TACE or cTACE at the First Affiliated Hospital of Zhengzhou University from October 2019 to September 2020 were retrospectively ana-lyzed,including 96 males and 17 females,aged(56.8±9.8)years old.According to treatment protocol,patients were divided into two groups:the D-TACE group(n=57)and the cTACE group(n=56).Liver fibrosis panel,fibrosis index(FIB-4),aspartate aminotransferase to platelet ratio index(APRI),and liver stiffness measurement(LSM)were compared between the groups at four timepoints:pre-treatment,one month after the first TACE,one month after the second TACE,and 12 months after the first TACE.Follow-ups were conducted through outpatient visits or telephone reviews to assess patient survivals.Data including the progression-free survival(PFS)and number of TACE sessions were compared between the two groups.Results The D-TACE group received 2.84±1.12 sessions of treatment during the observation period,com-pared to 4.05±1.44 sessions of cTACE group(t=4.94,P＜0.001).The median PFS in D-TACE and cTACE groups were 10.0 and 5.0 months,respectively(P＜0.001).At one month after the second TACE and at 12 months after the first TACE,patients in cTACE group had a higher serum levels of fibrosis markers including hyaluronic acid,type Ⅳ collagen,type Ⅲ procollagen N peptide and laminin than those in D-TACE group(all P＜0.05).At the same timepoints,patients in cTACE group also had higher APRI,FIB-4 and LSM than those in D-TACE group(all P＜0.05).Conclusion Compared to cTACE,patients in D-TACE group received fewer sessions of treatment during the first year after initial TACE,and the degree of liver fibrosis was also lower in D-TACE group.
维普
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