Objective To explore whether acute pancreatitis,chronic pancreatitis and alcoholic pancreatitis are related to the incidence of pancreatic cancer in Mendelian randomization study.Methods Using data from a genome-wide association study(GWAS)of European ancestry,the pancreatic cancer data in the UK population is obtained from the GWAS.Acute,chronic,and alcoholic pancreatitis data in the Finnish population is obtained from the Finnish database version R10.The correlation between acute,chro-nic pancreatitis,alcoholic pancreatitis and pancreatic cancer was analyzed by two-sample Mendelian randomi-zation through five Mendelian analysis methods mainly based on inverse variance weighting.Q heterogeneity test,pleiotropy test and reverse test were carried out to ensure the robustness of the results.Results Chro-nic pancreatitis was positively associated with pancreatic cancer(OR=1.332,95％CI:1.044-1.698,P=0.021).The results of Q heterogeneity test,pleiotropy test and reverse Mendelian randomization showed that the conclusions were reliability,all P＞0.05.While acute pancreatitis(P=0.953),acute alcoholic pancreatitis(P=0.862)and chronic alcoholic pancreatitis(P=0.682)were not significantly associated with pancreatic cancer.Conclusion This study further confirmed the strong correlation between chronic pancreatitis and pancreatic cancer at the genetic level.
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