Liver ischemia-reperfusion injury(IRI)is a significant factor contributing to liver dys-function following surgical procedures such as liver transplantation and hepatectomy,and its pathogenesis is closely associated with oxidative stress and immune responses.However,effective prevention and therapeutic strategies are still lacking.Short-chain fatty acids(SCFAs),primarily produced by the fermentation of gut microbiota,are the major source of these acids in the human body.Research has indicated that SCFAs play a significant role in oxidative stress and immune response.This review primarily focuses on the advancements on the role of SCFAs,the main metabolic byproducts of gut microbiota,in liver IRI,with a view to provide insights for the development of prevention and treatment strategies for liver IRI.
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