Objective To compare the prognosis of patients with hepatolithiasis-associated intrahe-patic cholangiocarcinoma(ICC)and hepatitis B virus(HBV)-associated ICC after radical resection.Methods The clinicopathological and survival data of 69 patients with ICC undergoing radical resection in the Department of Hepatobiliary and Pancreatic Surgery,Lihuili Hospital Affiliated to Ningbo University from January 2012 to February 2024 were retrospectively analyzed,including 40 males and 29 females,aged(62.9±10.2)years.Patients were divided into the stone group(n=40,with hepatolithiasis)and HBV group(n=29,with HBV).Kaplan-Meier method was used for survival analysis,and log-rank test was used for survival rate comparison.Cox proportional hazard regression model was used for multivariate analysis to analyze the effect of hepatolithiasis and HBV on the prognosis.Results The median overall survival of ICC patients in the stone group was 16 months,and that in the HBV group was 27 months.The.1-,3-,and 5-year cumulative survivals of the stone group were 56.6％,23.2％,and 10.3％,respectively,which were lower than those of the HBV group(72.0％,50.7％,and 43.4％,respectively,x2=5.95,P=0.015).The median recurrence-free survivals(RFS)of the stone group and the HBV group were 12 months and 23 months,respectively.The 1-year and 3-year RFS of the stone group were 49.2％and 18.1％,which were lower than those of the HBV group(65.0％and 39.8％,respectively,x2=3.94,P=0.047).Univariate analysis showed that hepatolithiasis was assciated with prognosis(x2=5.95,P=0.015).Multivariate Cox regression analysis showed that hepatolithiasis and hepatitis B virus infection had no effect on the prognosis of ICC patients after surgery(all P＞0.05).Conclusion Compared to HBV infection,ICC patients with hepatolithiasis have a worse prognosis.Hepatolithiasis and HBV infection have no effect on the prognosis of ICC after radical resection.
关键词
胆管上皮癌/肝内胆管结石/乙型肝炎病毒/预后
Key words
Cholangiocarcinoma/Hepatolithiasis/Hepatitis B virus/Prognosis
维普
万方数据