摘要
目的 基于4家三甲医院的多中心数据,分析无锡市急性胰腺炎(AP)的临床特征.方法 回顾性分析2006年1月1日至2009年12月30日与2020年1月1日至2023年12月30日两个时间段内,在江南大学附属医院、宜兴市人民医院、江阴市中医院和江阴市人民医院诊治的1 254例AP患者的临床资料,其中男性743例,女性511例,年龄53(40,67)岁.依据纳入的时间段将患者分为两组:2006～2009年组(n=456)和2020～2023年组(n=798).收集患者的一般临床特征、病因、实验室指标、影像学指标、并发症及预后等临床资料.结果 与2006～2009年组相比,2020～2023年组中胆源性 AP[60.6％(484/798)比 46.5％(212/456)]、高脂血症性 AP[11.2％(89/798)比 4.2％(19/456)]的比例增加,合并糖尿病[22.1％(176/798)比 7.2％(33/456)]、高血压[32.1％(256/798)比13.6％(62/456)]的比例均增加,差异均具有统计学意义(均P＜0.05).与2006～2009年组相比,2020～2023年组症状出现至入院的间隔时间变长[2.0(1.0,4.0)d比1.0(0.5,3.0)d],住院时间缩短[10(8,13)d 比 13(8,19)d],好转人数所占比例增加[85.6％(683/798)比 56.4％(257/456)],但是治愈人数所占比例降低[12.2％(97/798)比39.7％(181/456)],术后并发酮症酸中毒的患者所占比例增加[1.90％(15/798)比0.22％(1/456)],差异均具有统计学意义(均P＜0.05).在2006～2009年组和2020～2023年组中,AP发病人数最多的季节均为春季.结论 无锡市胆源性AP的发生率呈上升趋势,高血压、糖尿病和高脂血症是主要病因,春季为AP的高发季节.
Abstract
Objective To analyze the clinical characteristics of acute pancreatitis(AP)in Wuxi city based on multi center data from four tertiary hospitals.Methods A retrospective analysis was conduc-ted on the clinical data of 1 254 AP patients treated at Affiliated Hospital of Jiangnan University,Yixing Peo-ple's Hospital,Jiangyin Hospital of Traditional Chinese Medicine,and Jiangyin Peoples Hospital from Janu-ary 1,2006 to December 30,2009 and January 1,2020 to December 30,2023,including 743 males and 511 females,aged 53(40,67)years.The patients were divided into two groups based on the time period of inclusion:the 2006-2009 group(n=456)and the 2020-2023 group(n=798).Clinical data such as general clinical characteristics,etiology,laboratory parameters,imaging parameters,complications and prognosis were collected.Results Compared with the 2006-2009 group,the 2020-2023 group had an increased proportion of biliary AP[60.6％(484/798)vs.46.5％(212/456)],hyperlipidemic AP[11.2％(89/798)vs.4.2％(19/456)],comorbid diabetes mellitus[22.1％(176/798)vs.7.2％(33/456)],and hypertension[32.1％(256/798)vs.13.6％(62/456)],all of which were statistically significant(all P＜0.05).Compared with the 2006-2009 group,the interval between symptom onset and admission to the hospital became longer in the 2020-2023 group[2.0(1.0,4.0)d vs.1.0(0.5,3.0)d],the length of hospitalization was shorter[10(8,13)d vs.13(8,19)d],and the proportion of the number of people who got better was increased[85.6％(683/798)vs.56.4％(257/456)]but the proportion of the number of people who were cured was decreased[12.2％(97/798)vs.39.7％(181/456)],and the proportion of patients with postoperative complications of ketoacidosis increased[1.90％(15/798)vs.0.22％(1/456)],with the differences statistically significant(all P＜0.05).In both groups,the season with the highest number of AP cases was spring.Conclusion The incidence of biliary AP in Wuxi City is on the rise,hypertension,meanwhile diabetes mellitus and hyperlipidemia emerge as the predominant etio-logic factors,and spring is the high incidence season of AP.
维普
万方数据