Intraosseous regional administration(IORA)combines intraosseous infusion with tourniquet technology,using the tourniquet to limit the distribution of drugs in the target limb,achieving higher tissue concentration than systemic administra-tion.In recent years,IORA technology has gained widespread attention and application in total knee arthroplasty(TKA).At pres-ent,prophylactic antibiotics are mainly administered in TKA by IORA technology.Studies have shown that drug concentration in local tissues can be significantly increased by IORA before TKA.In addition,there are also studies using IORA technology for pre-operative analgesia in TKA,and good early postoperative analgesia effect has been obtained.However,it is unclear whether giving antibiotics through IORA technology is effective in preventing artificial joint infections.At the same time,there is still controversy as to whether IORA will increase complications such as puncture site accidents and fat embolism.This study reviews the current research on the use of IORA in TKA and shows that the application of IORA in TKA will not increase the incidence of complica-tions and can significantly increase the local drug concentration.In primary TKA,IORA technology may have advantages over tra-ditional intravenous systemic administration in terms of postoperative infection prevention and pain control.However,the efficacy of prophylactic antibiotics administered through IORA technology is unclear in people at high risk of infection such as obesity,dia-betes,and modified TKA.
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