摘要
骨关节炎(osteoarthritis,OA)是一种常见的关节慢性退行性疾病,是导致慢性疼痛和残疾的主要原因之一.多项研究表明OA与许多因素存在因果关联,如细胞因子、代谢性疾病、营养物质、肠道菌群和生活行为等.危险因素包括肥胖、高血脂水平和骨矿物质密度等,保护因素包括使用保钾利尿剂和醛固酮拮抗剂、叶酸和精氨酸等.这些因素主要通过参与机体的炎症反应和物质代谢过程或通过改变负重关节的生物力学从而影响OA的进展.此外,OA的慢性疼痛症状、炎性因子的表达以及非甾体类抗炎药的使用可能会增加其他疾病的患病风险,如2型糖尿病、重度抑郁症和帕金森病.孟德尔随机化是一种探索疾病与危险因素之间因果关联的新方法,该方法利用遗传变异的随机分配模拟随机对照试验,使用与危险因素相关的工具变量与疾病进行分析,从而检验两者之间的因果关联.本综述纳入OA的孟德尔随机化相关研究,分析OA与代谢性疾病、心血管疾病、骨骼肌肉系统疾病、中枢神经系统疾病、精神疾病、细胞因子、代谢组学、营养物质、肠道菌群、生活行为以及端粒长度和线粒体异质性之间的因果关联,对OA的预防和治疗具有重要意义.
Abstract
Osteoarthritis(OA)is a common chronic degenerative disease of joints,which is one of the main causes of chronic pain and disability.Several studies have shown that OA is causally associated with many factors,such as cytokines,meta-bolic diseases,nutrients,gut microbiota,and life behaviors.The risk factors included obesity,hyperlipidemia and bone mineral density,and the protective factors included the use of potassium-sparing diuretics and aldosterone antagonists,folic acid and argi-nine.These factors influence the progression of OA mainly by participating in the body's inflammatory response and material meta-bolic processes or by altering the biomechanics of weight-bearing joints.In addition,the chronic pain symptoms of OA,the expres-sion of inflammatory factors,and the use of non-steroidal anti-inflammatory drugs may increase the risk of other diseases,such as type 2 diabetes,severe depression,and Parkinson's disease.Mendelian randomization is a new method to explore the causal asso-ciation between diseases and risk factors.This method uses the random allocation of genetic variants to simulate randomized con-trolled trials and uses the instrumental variables related to risk factors and diseases to test the causal association between them.This review included the Mendelian randomization-related studies of OA and analyzed the causal association between OA and met-abolic diseases,cardiovascular diseases,musculoskeletal diseases,central nervous system diseases,psychiatric diseases,cyto-kines,metabolomics,nutrients,gut microbiota,life behavior,telomere length and mitochondrial heterogeneity,which is of great sig-nificance for the prevention and treatment of OA.
基金项目
陕西省教育厅服务地方专项(22JC027)
咸阳市科技重大专项(2020k01-08)
咸阳市重大科技创新专项(L2023-ZDKJ-CYJQ-SF-006)
NETL
NSTL
万方数据