Advances in osteoinductivity and tissue engineering applications of β-TCP
杜锦洲 1钱运 1范存义1
扫码查看
点击上方二维码区域，可以放大扫码查看
作者信息
1. 上海交通大学医学院附属第六人民医院(国家骨科医学中心)骨科,上海 200233
折叠
摘要
目前,在临床中仅应用自体骨已不能满足骨缺损治疗的需求.β-磷酸三钙(beta-tricalcium phosphate,β-TCP)类骨移植替代物因具有良好的修复效果和一定的骨诱导能力而受到广泛关注.可降解β-TCP植入人体后可有效调控炎症,促进血管再生,并以膜内成骨的方式形成新骨,实现骨缺损的愈合.对β-TCP诱导间质干细胞分化为成骨细胞机制的探索也从未停止,最初将骨诱导性归功于被释放钙磷离子和被吸附蛋白的功能,最近的研究热点是材料表面结构对细胞的影响(即整合素与细胞骨架被改变),以及调节信号通路的传导,包括丝裂原活化蛋白激酶/细胞外信号调节激酶(mitogen-activated protein kinase,MAPK/extracellular regulated protein kinases,ERK)通路、WNT家族分泌蛋白通路、Hippo-Yes 相关蛋白/转录共激活因子(Yes-associated protein,YAP/transcriptional coactivator with PDZ-binding motif,TAZ)通路等.目前,β-TCP产品的基础结构日趋成熟,宏观与微观设计也被不断创新,相关骨移植替代物广泛用于临床,经临床研究证实具有长期的安全性和有效性.
Abstract
The use of autogenous bone in treating bone defects has not met clinical demands,leading to increased atten-tion on beta-tricalcium phosphate(β-TCP)as a bone graft substitute due to its effective repair capabilities and inherent osteoinduc-tive properties.Upon implantation,biodegradable β-TCP can effectively modulate inflammation,promote vascular regeneration,and facilitate new bone formation through intramembranous ossification,thereby achieving bone defect healing.Continuous re-search has sought to understand the mechanisms underlying β-TCP's ability to induce mesenchymal stem cell differentiation into osteoblasts,initially attributed to the release of calcium and phosphorus ions and the adsorption of proteins.Current research em-phasizes the impact of the material's surface structure on cellular interactions,particularly focusing on changes in cell-integrin and cytoskeleton dynamics,which regulate signal transduction pathways such as the mitogen-activated protein kinase/extracellular signal-regulated kinases(MAPK/ERK)pathway,the Wnt pathway,and the Yes-associated protein/transcriptional coactivator with PDZ-binding motif(Yap/Taz)pathway.Presently,the fundamental structure of β-TCP products has matured,with continuous inno-vations in macro and micro design.These bone graft substitutes are widely used in clinical settings,demonstrating long-term safety and efficacy.
维普
万方数据