Reactive oxygen species play a crucial role in maintaining metabolic balance in the body.They are not only im-portant mediators in maintaining a normal physiological environment,but also important triggers for the occurrence and development of many diseases.Osteoarthritis is the most common degenerative joint disease at present.Due to the aging population,extended life expectancy and obesity,the incidence rate and prevalence of osteoarthritis have increased year by year.Recent studies on osteoarthri-tis show that reactive oxygen species play a crucial role in its occurrence and development,and are key factors leading to extracellu-lar matrix degradation,mitochondrial dysfunction,chondrocyte apoptosis and the progress of osteoarthritis.For osteoarthritis,moder-ate levels of reactive oxygen species can promote the proliferation of chondrocytes and the formation of cartilage matrix.However,ex-cessive accumulation of reactive oxygen species can induce oxidative stress,leading to degeneration of chondrocytes and breakdown of cartilage matrix,ultimately resulting in the occurrence of osteoarthritis and many other metabolic diseases.In recent years,hydro-gels have attracted attention as new biomaterials for the treatment of osteoarthritis.Reactive oxygen scavenging hydrogels are a new type of polymer biomaterials with drug intelligent delivery function that can regulate tissue oxidative stress and inflammatory reaction.They mainly include traditional reactive oxygen scavenging hydrogels with the main function of loading reactive oxygen scavenging drugs and reactive oxygen responsive hydrogels with reactive oxygen responsive groups.The former mainly uses slow-release drugs with reactive oxygen species scavenging properties encapsulated in it to treat osteoarthritis,while the latter can not only clear the reac-tive oxygen species generated during the occurrence and development of osteoarthritis by breaking the reactive oxygen species respon-sive groups,but also responsively deliver various drugs for treating osteoarthritis.Reactive oxygen scavenging hydrogels have a good prospect in the treatment of osteoarthritis and repair.
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