Chronic hepatitis B virus(HBV)infection will greatly contribute to raising the occurrence probability of cirrhosis and hepatocellular carcinoma in patients.Although existing antiviral treatment regimens have a certain effect on delaying disease progression and improving prognosis,it is still not effective in attaining functional cures.Hepatitis B virus DNA integration may be one of the reasons for this phenomenon.Therefore,this paper reviews the possible mechanisms of HBV DNA integration in maintaining chronic inflammation of the liver,evading existing antiviral treatment methods,and inducing hepatocellular carcinoma so as to further deepen the understanding of the role of HBV DNA integration in the occurrence and development of chronic hepatitis B,providing ideas and references for formulating better treatment strategies.
关键词
乙型肝炎病毒/整合HBV/DNA/慢性乙型肝炎病毒感染/病毒复制/功能性治愈
Key words
Hepatitis B virus/Integrated HBV DNA/Chronic hepatitis B virus infection/Viral replication/Functional cure
维普
万方数据