Hepatitis B surface antigen(HBsAg)negative seroconversion(HBsAg＜0.05 IU/ml)is research hotspot in the field of hepatitis at this stage,and patients who achieve HBsAg negative seroconversion have significantly fewer liver-related complications.Presently,there are many studies with regard to HBsAg-negative seroconversion,but there are still relatively few indicators used in clinical practice to predict HBsAg-negative seroconversion.Low baseline HBsAg quantification and dynamic decline during treatment are currently recognized as the best indicators for predicting HBsAg-negative seroconversion.However,other factors such as viral genotype,elevated transaminases during treatment course,immune cell function and cytokine levels,and host factors can all influence HBsAg-negative seroconversion.This article reviews the relevant indicators and potential predictive factors for HBsAg-negative seroconversion.
关键词
慢性乙型肝炎/乙型肝炎表面抗原/临床治愈/预测因子
Key words
Chronic hepatitis B/Hepatitis B surface antigen/Clinical cure/Predictor
维普
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