Spatial distribution pattern of local tumor progression analysis after microwave ablation of hepatocellular carcinoma based on three-dimensional magnetic resonance imaging
Spatial distribution pattern of local tumor progression analysis after microwave ablation of hepatocellular carcinoma based on three-dimensional magnetic resonance imaging
Objective To investigate the spatial distribution pattern of local tumor progression(LTP)for hepatocellular carcinoma(HCC)＜5 cm after microwave ablation.Methods A retrospective analysis was performed on 169 HCCs with matched MRI before and after ablation from December 2009 to December 2019.A tumor MRI was reconstructed using three-dimensional visualization technology.LTP was classified as contact or non-contact,early or late stage,according to whether LTP was in contact with the edge of the ablation zone and the occurrence time(24 months).The tumor-surrounded area was divided into eight quadrants by using the eight-quadrant map method.An analysis was conducted on the spatial correlation between the quadrant where the ablative margin(AM)safety boundary was located and the quadrant where different types of LTP occurred.The t-test,or rank-sum test,was used for the measurement data.2-test for count data was used to compare the difference between the two groups.Results The AM quadrant had a distribution of 54.4％LTP,64.2％early LTP stage,and 69.1％contact LTP,suggesting this quadrant was much more concentrated than the other quadrants(P＜0.001).Additionally,the AM quadrant had only 15.2％of non-contact type LTP and 17.1％of late LTP,which was not significantly different from the average distribution probability of 12.5％(100/8％)among the eight quadrants(P=0.667,0.743).46.6％of early contact type LTP was located at the ablation needle tip,25.2％at the body,and 28.1％at the caudal,while the location distribution probabilities of non-early contact LTP were 34.8％,31.8％,and 33.3％,respectively.Conclusion LTP mostly occurs in areas where the ablation safety boundary is the shortest.However,non-contact LTP and late LTP stages exhibit the feature of uniform distribution.Thus,this type of LPT may result from an inadequate non-ablation safety boundary.
关键词
肝细胞癌/微波消融/局部进展/空间规律
Key words
Hepatocellular carcinoma/Thermal ablation/Recurrence/Spatial distribution characteristics
维普
万方数据