Non-alcoholic fatty liver disease(NAFLD)has gradually become the most prevalent chronic liver disease in the world,but its pathogenesis has not been fully elucidated.Ferroptosis is a novel type of programmed cell death caused by iron-dependent lipid peroxidation.Heme oxygenase-1 is a recognized antioxidant enzyme and an important regulatory factor in ferroptosis that modulates ferroptosis through various pathways and,in turn,regulates NAFLD.This paper reviews the regulatory mechanism of heme oxygenase-1 on NAFLD in ferroptosis pathway,with a view to clarifying the occurrence and development mechanisms of NAFLD and providing new vision and targets for its prevention and treatment.
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