中华肝脏病杂志2024,Vol.32Issue(4) :303-305.DOI:10.3760/cma.j.cn501113-20240226-00095

肝纤维化新药临床研发的挑战及其优化策略

Challenges and optimization strategies for clinical research and the development of new drugs for liver fibrosis

蔡晓波 曲颖 陆伦根
中华肝脏病杂志2024,Vol.32Issue(4) :303-305.DOI:10.3760/cma.j.cn501113-20240226-00095

肝纤维化新药临床研发的挑战及其优化策略

Challenges and optimization strategies for clinical research and the development of new drugs for liver fibrosis

蔡晓波 1曲颖 1陆伦根1
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作者信息

  • 1. 上海交通大学医学院附属第一人民医院消化内科,上海 200080
  • 折叠

摘要

肝纤维化是各种慢性肝病向肝硬化发展过程中的关键步骤,如何能通过药物逆转肝纤维化始终为肝病领域研究的重点和难点.然而,由于机制复杂、终点评估困难、缺少无创诊断方法等因素,一些新的药物正在研发中,肝纤维化新药研发道阻且长,但前景乐观.

Abstract

Liver fibrosis is a key step in the developmental process of various chronic liver diseases,including cirrhosis.Therefore,the focus and difficulty of liver disease research have always been on how to reverse liver fibrosis.However,due to complex mechanisms,difficulties in endpoint evaluation,a lack of non-invasive diagnostic methods,and other factors,the research and development of new drugs are hindered and lengthy.Currently,some new drugs are being researched and developed,which signifies the prospect is optimistic.

关键词

肝纤维化/新药/研发和应用

Key words

Liver fibrosis/New drugs/Research and development

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基金项目

国家重点研发计划(2022YFC3502101)

出版年

2024
中华肝脏病杂志
中华医学会

中华肝脏病杂志

CSTPCDCSCD北大核心
影响因子:1.625
ISSN:1007-3418
参考文献量16
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